BIOLOGICAL SIGNIFICANCE

Haemocoagulase is a mixture of purified enzymes isolated from the venom of a South American viper, called Bothrops atrox. It is completely free of neurotoxins and other toxic substances. It is a pale yellow crystalline powder, which is sparingly soluble in water, but readily soluble in phenolated saline. It is active over a wide pH range of 4 to 8. Haemocoagulase shortens the bleeding and clotting time, by promoting coagulation at bleeding sites and reduces blood loss.

CLINICAL USE

Used to decrease or stop bleeding in every clinical treatment, for example, in surgery, internal medicine, obstetrics and gynecology, ophthalmology, ear-throat-nose, stomatology.

It can also be used to prevent from bleeding, for example, before operation. This will decrease or avoid bleeding on the wound during the operation and after the operation.

Haemocoagulase is indicated in all fields of medicine, i.e. gynaecology, urology, gastro-enterology, dentistry for the prevention and treatment of haemorrhages of various origins, including cases where surgical treatment is required

MODE OF ACTION

Haemocoagulase has two different enzymatic activities, which promote blood coagulation. One of these accelerates the conversion of prothrombin to thrombin (thromboplastin like enzymes), while the other one causes a direct transformation of fibrinogen to fibrin monomer, which can be converted by thrombin into fibrin clot (thrombin like enzymes).